Design of Experiments (DoE) was conducted using three variables: roller compactor type, mill type and target ribbon porosity ().The roller compactors compared in this study were: Gerteis MiniPactor (Gerteis, Rapperswil-Jona, Switzerland), Hosokawa Bepex Pharmapaktor C250/30 (Hosokawa , Leingarten, Germany) and Alexanderwerk WP120 Pharma (Alexanderwerk , Remscheid, …